The use of non-selective beta-blockers in patients with cirrhosis: more doubts than certainties
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چکیده
منابع مشابه
Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties".
REPLY: In their letter to the editor, in this issue of the American Journal of Physiology-Lung Cellular and Molecular Physiology, Caruso and colleagues (3) reprise longstanding arguments that the tobacco industry uses to cast doubt on evidence linking smoking with disease (7) to question our conclusion that e-cigarettes pose important potential pulmonary risks (4). They argue that we have syste...
متن کاملIs the use of non-selective beta-blockers necessary in cirrhotic patients with small varices?
Non-selective β-blockers (NSBBs) could eff ectively prevent the development of fi rst variceal bleeding in cirrhotic patients with medium/large varices. However, as recently reviewed by Giannelli et al [1], the clinical benefi t of NSBBs remains controversial in cirrhotic patients with small varices. In line with their considerations, we would like to further comment on the controversy. A previ...
متن کاملNonselective Beta-blockers in Patients with Cirrhosis: "the Therapeutic Window".
For over 30 years, nonselective beta-blockers (NSBB) have been successfully used for preventing variceal bleeding in patients with cirrhosis and portal hypertension. Nevertheless, recent studies suggest that NSBB may be effective only within a particular "therapeutic window" in patients with advanced liver disease. Outside of this window, in early stages of cirrhosis and in very advanced cirrho...
متن کاملBeta-blockers to prevent gastroesophageal varices in patients with cirrhosis.
BACKGROUND Nonselective beta-adrenergic blockers decrease portal pressure and prevent variceal hemorrhage. Their effectiveness in preventing varices is unknown. METHODS We randomly assigned 213 patients with cirrhosis and portal hypertension (minimal hepatic venous pressure gradient [HVPG] of 6 mm Hg) to receive timolol, a nonselective beta-blocker (108 patients), or placebo (105 patients). T...
متن کاملBeta-blockers in liver cirrhosis
Since the original description of the effectiveness of β-blockers in lowering the portal pressure and therefore the risk of variceal bleeding, more than 500 articles in the English literature on the use of non selective β-blockers (NSBB) in cirrhosis have been published. The use of NSBB in pre-primary prophylaxis of variceal bleeding is currently not indicated. In primary prophylaxis, patients ...
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ژورنال
عنوان ژورنال: AME Medical Journal
سال: 2017
ISSN: 2520-0518
DOI: 10.21037/amj.2017.08.08